DHEA: The Sexy, Anti-Wrinkle Hormone DHEA (dihydoepiandrosterone), a natural neurosteroid produced in the adrenal glands, is an abundant hormone in the body. It is a testosterone supplement that helps you to fight Low-Testosterone Syndrome—which refers to loss of testosterone and DHEA. DHEA supplements can restore youthful qualities that aging women and men lose due to lower systemic testosterone due to male menopause or andropause and female hormone imbalance during menopause.